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Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome.
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Under load, this creates GC pressure that can devastate throughput. The JavaScript engine spends significant time collecting short-lived objects instead of doing useful work. Latency becomes unpredictable as GC pauses interrupt request handling. I've seen SSR workloads where garbage collection accounts for a substantial portion (up to and beyond 50%) of total CPU time per request — time that could be spent actually rendering content.